Posted by: kelsijo97 | February 15, 2013

March 2013

Alexander, David L. “American Indian Studies, Multiculturalism, and the Academic Library.” [In English]. College & Research Libraries74, no. 1 (Jan 2013): 60-68.
 
The current status of multicultural and diversity efforts suggests the need for incorporating into the discussion of librarianship an understanding of previously underrepresented populations such as the American Indian. American Indian Studies speaks from the American Indian perspective and addresses the contemporary condition of American Indians. This article discusses the nature of American Indian Studies and provides suggestions for what librarians can do to support American Indian Studies programs and American Indian students. This example illustrates the importance of acknowledging the validity of diverse worldviews.
 
Library Faculty.
 
 
Arendt, David H., Patrick J. Ronan, Kevin D. Oliver, Leah B. Callahan, Tangi R. Summers, and Cliff H. Summers. “Depressive Behavior and Activation of the Orexin/Hypocretin System.” Behavioral Neuroscience127, no. 1 (2013): 86-94.
 
The orexin/hypocretin peptide signaling system plays a neuromodulatory role in motivation and stress; two critical components of depression. Although work has been done to identify links between orexin and depression, few specific neuroanatomical associations have been made. These studies have not investi-gated the relationship between orexin and orexin receptor expression in specific brain regions associated with this disorder. To address this, we examined immobility during the forced swim test (FST) in mice, a commonly used measure of depressive behavior. We analyzed the variation in FST immobility with the distribution of orexin and its receptor mRNA. We found that animals that exhibited more robust depressive behavior had greater or lesser orexin system expression that depended on the limbic brain region analyzed. In the hippocampus there was a negative correlation between orexin expression and FST immobility. Animals that displayed relatively more depressive behavior had lower hippocampal expres-sion of Orexin A (OrxA). In the amygdala, there was a curvilinear relationship between OrxA and FST performance. In addition there was a positive correlation with amygdalar Type I orexin receptor (Orx1) mRNA and depressive behavior. Despite the differences in limbic orexin expression, there was no correlation between immobility and hypothalamic orexin neuron activation as measured by c-Fos. Overall, more severe depressive behavior was associated with reduced hippocampal orexin expression, contrasted with increased orexin plus Orx1 receptor mRNA expression in the amygdala. This divergent pattern between the hippocampus and amygdala mirrors a neurobiological theme seen in depression resulting from reduced hippocampal, but increased amygdalar, size and function.
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Arendt, David H., Justin P. Smith, C. C. Bastida, M. S. Prasad, Kevin D. Oliver, Kathleen M. Eyster, Tangi R. Summers, Y. Delville, and Cliff H. Summers. “Contrasting Hippocampal and Amygdalar Expression of Genes Related to Neural Plasticity During Escape from Social Aggression.” [In English]. Physiology & Behavior107, no. 5 (Dec 2012): 670-79.
 
Social subjugation has widespread consequences affecting behavior and underlying neural systems. We hypothesized that individual differences in stress responsiveness were associated with differential expression of neurotrophin associated genes within the hippocampus and amygdala. To do this we examined the brains of hamsters placed in resident/intruder interactions, modified by the opportunity to escape from aggression. In the amygdala, aggressive social interaction stimulated increased BDNF receptor TrK(B) mRNA levels regardless of the ability to escape the aggressor. In contrast, the availability of escape limited the elevation of GluR(1) AMPA subunit mRNA In the hippocampal CA(1), the glucocorticoid stress hormone, cortisol; was negatively correlated with BDNF and TrK(B) gene expression, but showed a positive correlation with BDNF expression in the DG. Latency to escape the aggressor was also negatively correlated with CA(1) BDNF expression. In contrast, the relationship between TrK(B) and GluR(1) was positive with respect to escape latency. These, results suggest that an interplay of stress and neurotrophic systems influences learned escape behavior. Animals which escape faster seem to have a more robust neurotrophic profile in the hippocampus, with the opposite of this pattern in the amygdala. We propose that changes in the equilibrium of hippocampal and amygdalar learning result in differing behavioral stress coping choices. (C) 2012 Published by Elsevier Inc.
 
Biology Department.
 
 
Barr, Jeffrey L., Jamie L. Scholl, Rajeshwari R. Solanki, Michael J. Watt, Christopher A. Lowry, Kenneth J. Renner, and Gina L. Forster. “Influence of Chronic Amphetamine Treatment and Acute Withdrawal on Serotonin Synthesis and Clearance Mechanisms in the Rat Ventral Hippocampus.” [In English]. The European journal of neuroscience37, no. 3 (2013 Feb (Epub 2012 Nov 2013): 479-90.
 
Amphetamine withdrawal in both humans and rats is associated with increased anxiety states, which are thought to contribute to drug relapse. Serotonin in the ventral hippocampus mediates affective behaviors, and reduced serotonin levels in this region are observed in rat models of high anxiety, including during withdrawal from chronic amphetamine. This goal of this study was to understand the mechanisms by which reduced ventral hippocampus serotonergic neurotransmission occurs during amphetamine withdrawal. Serotonin synthesis (assessed by accumulation of serotonin precursor as a measure of the capacity of in vivo tryptophan hydroxylase activity), expression of serotonergic transporters, and in vivo serotonergic clearance using in vivo microdialysis were assessed in the ventral hippocampus in adult male Sprague Dawley rats at 24h withdrawal from chronic amphetamine. Overall, results showed that diminished extracellular serotonin at 24h withdrawal from chronic amphetamine was not accompanied by a change in capacity for serotonin synthesis (in vivo tryptophan hydroxylase activity), or serotonin transporter expression or function in the ventral hippocampus, but instead was associated with increased expression and function of organic cation transporters (low-affinity, high-capacity serotonin transporters). These findings suggest that 24h withdrawal from chronic amphetamine reduces the availability of extracellular serotonin in the ventral hippocampus by increasing organic cation transporter-mediated serotonin clearance, which may represent a future pharmacological target for reversing anxiety states during drug withdrawal. 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Basa, Prem N., and Andrew G. Sykes. “Differential Sensing of Zn(Ii) and Cu(Ii) Via Two Independent Mechanisms.” [In English]. Journal of Organic Chemistry77, no. 19 (Oct 2012): 8428-34.
 
Selective reduction of an anthracenone-quinoline imine derivative, 2, using 1.0 equiv of NaBH(4) in 95% ethanol affords the corresponding anthracen-9-ol derivative, 3, as confirmed by (1)H NMR, (13)C NMR, ESI-MS, FTIR, and elemental analysis results. UV-vis and fluorescence data reveal dramatic spectroscopic changes in the presence of Zn(II) and Cu(II). Zinc(II) coordination induces a 1,5-prototropic shift resulting in anthracene fluorophore formation via an imine-enamine tautomerization pathway. Copper(II) induces a colorimetric change from pale yellow to orange-red and results in imine hydrolysis in the presence of water. Spectroscopic investigations of metal ion response, selectivity, stoichiometry, and competition studies all suggest the proposed mechanisms. ESI-MS analysis, FTIR, and single-crystal XRD further support the hydrolysis phenomenon. This is a rare case of a single sensor that can be used either as a chemosensor (reversibly in the case of Zn(II)) or as a chemodosimeter (irreversibly in the case of Cu(II)); however, the imine must contain a coordinating Lewis base, such as quinoline, to be active for Cu(II).
 
Chemistry Department.
 
 
Brandhagen, Breeann N., Chelsea R. Tieszen, Tara M. Ulmer, Maria S. Tracy, Alicia A. Goyeneche, and Carlos M. Telleria. “Cytostasis and Morphological Changes Induced by Mifepristone in Human Metastatic Cancer Cells Involve Cytoskeletal Filamentous Actin Reorganization and Impairment of Cell Adhesion Dynamics.” [In English]. BMC cancer13, no. / (2013 2013): 35.
 
UNLABELLED: ABSTRACT:; BACKGROUND: Changes in cell shape and plasticity in cytoskeletal dynamics are critically involved in cell adhesion, migration, invasion and the overall process of metastasis. Previous work in our laboratory demonstrated that the synthetic steroid mifepristone inhibited the growth of highly metastatic cancer cells, while simultaneously causing striking changes in cellular morphology. Here we assessed whether such morphological alterations developed in response to cytostatic concentrations of mifepristone are reversible or permanent, involve rearrangement of cytoskeletal proteins, and/or affect the adhesive capacity of the cells.; METHODS: Cancer cell lines of the ovary (SKOV-3), breast (MDA-MB-231), prostate (LNCaP), and nervous system (U87MG) were exposed to cytostatic concentrations of mifepristone and studied by phase-contrast microscopy. The transient or permanent nature of the cytostasis and morphological changes caused by mifepristone was assessed, as well as the rearrangement of cytoskeletal proteins. De-adhesion and adhesion assays were utilized to determine if mifepristone-arrested and morphologically dysregulated cells had abnormal de-adhesion/adhesion dynamics when compared to vehicle-treated controls.; RESULTS: Mifepristone-treated cells displayed a long, thin, spindle-like shape with boundaries resembling those of loosely adhered cells. Growth arrest and morphology changes caused by mifepristone were reversible in SKOV-3, MDA-MB-231 and U87MG, but not in LNCaP cells that instead became senescent. All cancer cell types exposed to mifepristone displayed greatly increased actin ruffling in association with accelerated de-adhesion from the culture plate, and delayed adhesion capacity to various extracellular matrix components.; CONCLUSIONS: Cytostatic concentrations of mifepristone induced alterations in the cellular structure of a panel of aggressive, highly metastatic cancer cells of different tissues of origin. Such changes were associated with re-distribution of actin fibers that mainly form non-adhesive membrane ruffles, leading to dysregulated cellular adhesion capacity.
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Burke, Andrew R., Gina L. Forster, Andrew M. Novick, Christina L. Roberts, and Michael J. Watt. “Effects of Adolescent Social Defeat on Adult Amphetamine-Induced Locomotion and Corticoaccumbal Dopamine Release in Male Rats.” [In English]. Neuropharmacology67 (2013 Apr (Epub 2012 Dec 2013): 359-69.
 
Maturation of mesocorticolimbic dopamine systems occurs during adolescence, and exposure to social stress during this period results in behavioral dysfunction including substance abuse disorders. Adult male rats exposed to repeated social defeat in adolescence exhibit reduced basal dopamine tissue content in the medial prefrontal cortex, altered dopamine tissue content in corticoaccumbal dopamine regions following acute amphetamine, and increased amphetamine conditioned place preference following repeated amphetamine treatment. Such changes may reflect altered amphetamine-induced extracellular dopamine release in the corticoaccumbal regions. Therefore, we used invivo microdialysis to measure extracellular dopamine simultaneously within the medial prefrontal cortex and nucleus accumbens core of previously defeated rats and controls, in response to either acute or repeated (7 daily injections) of amphetamine (1.0mg/kg). Locomotion responses to acute/repeated amphetamine were also assessed the day prior to taking dopamine measurements. Adolescent defeat potentiated adult locomotion responses to acute amphetamine, which was negatively correlated with attenuated amphetamine-induced dopamine release in the medial prefrontal cortex, but there was no difference in amphetamine-induced accumbal dopamine release. However, both locomotion and corticoaccumbal dopamine responses to repeated amphetamine were equivalent between previously defeated rats and controls. These data suggest adolescent defeat enhances behavioral responses to initial amphetamine exposure as a function of diminished prefrontal cortex dopamine activity, which may be sufficient to promote subsequently enhanced seeking of drug-associated cues. Interestingly, repeated amphetamine treatment appears to normalize amphetamine-elicited locomotion and cortical dopamine responses observed in adult rats exposed to adolescent social defeat, providing implications for treating stress-induced dopamine dysfunction. Copyright 2012 Elsevier Ltd. All rights reserved.
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Coleman, Robert L., Shamshad Ali, Charles F. Levenback, Michael A. Gold, Jeffrey M. Fowler, Patricia L. Judson, Maria C. Bell, et al. “Is Bilateral Lymphadenectomy for Midline Squamous Carcinoma of the Vulva Always Necessary? An Analysis from Gynecologic Oncology Group (Gog) 173.” Gynecologic Oncology128, no. 2 (2013): 155-59.
 
Abstract: Objective: To determine which patients with near midline lesions may safely undergo unilateral groin dissection based on clinical exam and lymphoscintigraphy (LSG) results. Methods: Patients participating in GOG-173 underwent sentinel lymph node (SLN) localization with blue dye, and radiocolloid with optional LSG before definitive inguinal–femoral lymphadenectomy (LND). This analysis interrogates the reliability of LSG alone relative to primary tumor location in those patients who had an interpretable LSG and at least one SLN identified. Primary tumor location was categorized as lateral (>2cm from midline), midline, or lateral ambiguous (LA) if located within 2cm, but not involving the midline. Results: Two-hundred-thirty-four patients met eligibility criteria. Sixty-four had lateral lesions, and underwent unilateral LND. All patients with LA (N=65) and midline (N=105) tumors underwent bilateral LND. Bilateral drainage by LSG was identified in 14/64 (22%) patients with lateral tumors, 38/65 (58%) with LA tumors and in 73/105 (70%) with midline tumors. At mapping, no SLNs were found in contralateral groins among those patients with LA and midline tumors who had unilateral-only LSGs. However, in these patients groin metastases were found in 4/32 patients with midline tumors undergoing contralateral dissection; none were found in 27 patients with LA tumors. Conclusion: The likelihood of detectable bilateral drainage using preoperative LSG decreases as a function of distance from midline. Patients with LA primaries and unilateral drainage on LSG may safely undergo unilateral SLN.
 
Sanford School of Medicine, Sioux Falls Campus.
 
 
Dahdul, Wasila M., J. P. Balhoff, D. C. Blackburn, A. D. Diehl, ……, and Paula M. Mabee. “A Unified Anatomy Ontology of the Vertebrate Skeletal System.” [In English]. Plos One7, no. 12 (Dec 2012).
 
The skeleton is of fundamental importance in research in comparative vertebrate morphology, paleontology, biomechanics, developmental biology, and systematics. Motivated by research questions that require computational access to and comparative reasoning across the diverse skeletal phenotypes of vertebrates, we developed a module of anatomical concepts for the skeletal system, the Vertebrate Skeletal Anatomy Ontology (VSAO), to accommodate and unify the existing skeletal terminologies for the species-specific (mouse, the frog Xenopus, zebrafish) and multispecies (teleost, amphibian) vertebrate anatomy ontologies. Previous differences between these terminologies prevented even simple queries across databases pertaining to vertebrate morphology. This module of upper-level and specific skeletal terms currently includes 223 defined terms and 179 synonyms that integrate skeletal cells, tissues, biological processes, organs (skeletal elements such as bones and cartilages), and subdivisions of the skeletal system. The VSAO is designed to integrate with other ontologies, including the Common Anatomy Reference Ontology (CARO), Gene Ontology (GO), Uberon, and Cell Ontology (CL), and it is freely available to the community to be updated with additional terms required for research. Its structure accommodates anatomical variation among vertebrate species in development, structure, and composition. Annotation of diverse vertebrate phenotypes with this ontology will enable novel inquiries across the full spectrum of phenotypic diversity.
 
Biology Department.
 
 
Hatch, C. D., M. J. Christie, R. M. Weingold, Chia-Ming Wu, D. M. Cwiertny, and J. Baltrusaitis. “Horizontal Attenuated Total Reflectance Fourier Transform Infrared and X-Ray Photoelectron Spectroscopy Measurements of Water Adsorption on Oxidized Tin(Ii) Sulfide (Sns) Surfaces.” [In English]. Journal of Physical Chemistry C 117, no. 1 (Jan 2013): 472-82.
 
Tin(II) sulfide (SnS) is considered to be a promising optoelectronic material due to its narrow band gap, strong optical absorption, low cost and nontoxic and chemically inert characteristics. As an inherently stable compound, SnS surfaces are expected to be hydrophobic by nature. However, exposure of pristine SnS surfaces to air inevitably leads to surface oxidation which can affect the mineral’s dissolution, reactivity, optical and electronic properties as well as hydrophobicity. In the present study,,water adsorption measurements on oxidized SnS thin films were performed using horizontal attenuated total reflection Fourier transform infrared (HATR-FTIR) spectroscopy. X-ray photoelectron spectroscopy (XPS) analysis allowed for characterization of the SnS surface composition before water vapor exposure and identification of any changes that occurred to the surface after water vapor exposure. XPS results are consistent with water adsorption occurring on SnS surfaces containing hydroxyl and carbonate groups. Additionally, XPS analysis showed that exposure of SnS to water vapor resulted in no significant changes to the original surface composition. Quantitative water adsorption measurements using HATR-FTIR spectroscopy show that the oxidized SnS surface exhibits a slightly hydrophilic nature, demonstrating multilayer water adsorption at high relative humidity (RH) values. Experimental water adsorption data were fit using the Brunauer-Emmett-Teller (BET) and Freundlich adsorption models. From these model fits, details of monolayer water adsorption and the water adsorption mechanisms were extracted to provide a better understanding of gas/surface adsorption on oxidized SnS surfaces. Results suggest that water adsorption on SnS powder occurs in three distinct regimes, including sub-monolayer water adsorption up to monolayer coverage at 13% RH, followed by filling of mesopores (13-76% RH) and finally multilayer water adsorption (>76% RH) via filling of macropores. This study represents the first report of in Situ water adsorption measurements on SnS as a function of relative humidity, illustrating how oxidized surface species can alter the hydrophobic nature of SnS surfaces.
 
Chemistry Department.
 
 
Hogarth, P., A. Gregory, Michael C. Kruer, L. Sanford, W. Wagoner, M. R. Natowicz, R. T. Egel, et al. “New Nbia Subtype Genetic, Clinical, Pathologic, and Radiographic Features of Mpan.” [In English]. Neurology80, no. 3 (Jan 2013): 268-75.
 
Objective: To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype. Methods: Samples from 161 individuals with idiopathic NBIA were screened, and C19orf12 mutations were identified in 23 subjects. Direct examinations were completed on 8 of these individuals, and medical records were reviewed on all 23. Histochemical and immunohistochemical studies were performed on brain tissue from one deceased subject. Results: A variety of mutations were detected in this cohort, in addition to the Eastern European founder mutation described previously. The characteristic clinical features of mitochondrial membrane protein-associated neurodegeneration (MPAN) across all age groups include cognitive decline progressing to dementia, prominent neuropsychiatric abnormalities, and a motor neuronopathy. A distinctive pattern of brain iron accumulation is universal. Neuropathologic studies revealed neuronal loss, widespread iron deposits, and eosinophilic spheroidal structures in the basal ganglia. Lewy neurites were present in the globus pallidus, and Lewy bodies and neurites were widespread in other areas of the corpus striatum and midbrain structures. Conclusions: MPAN is caused by mutations in C19orf12 leading to NBIA and prominent, widespread Lewy body pathology. The clinical phenotype is recognizable and distinctive, and joins pantothenate kinase-associated neurodegeneration and PLA2G6-associated neurodegeneration as one of the major forms of NBIA. Neurology (R) 2013;80:268-275
 
Sanford School of Medicine, Sioux Falls Campus.
 
 
Luo, J., K. Nguyen, M. Chen, T. Tran, ……, and Zhiguang Guo. “Evaluating Insulin Secretagogues in a Humanized Mouse Model with Functional Human Islets.” [In English]. Metabolism-Clinical and Experimental62, no. 1 (Jan 2013): 90-99.
 
Objective. To develop a rapid, easy and clinically relevant in vivo model to evaluate novel insulin secretagogues on human islets, we investigated the effect of insulin secretagogues on functional human islets in a humanized mouse model. Materials/Methods. Human islets were transplanted under the kidney capsule of streptozotocin (STZ)-induced diabetic mice with immunodeficiency. Human islet graft function was monitored by measuring non-fasting blood glucose levels. After diabetes was reversed, human islet transplanted mice were characterized physiologically by oral glucose tolerance and pharmacologically with clinically proven insulin secretagogues, glucagon-like peptide-1 (GLP-1), exenatide, glyburide, nateglinide and sitagliptin. Additionally, G protein-coupled receptor 40 (GPR40) agonists were evaluated in this model. Results. Long-term human islet graft survival could be achieved in immunodeficient mice. Oral glucose challenge in human islet transplanted mice resulted in an immediate incremental increase of plasma human C-peptide, while the plasma mouse C-peptide was undetectable. Treatments with GLP-1, exenatide, glyburide, nateglinide and sitagliptin effectively increased plasma human C-peptide levels and improved postprandial glucose concentrations. GPR40 agonists also stimulated human C-peptide secretion and significantly improved postprandial glucose in the human islet transplanted mice. Conclusions. Our studies indicate that a humanized mouse model with human islet grafts could mimic the in vivo characteristics of human islets and could be a powerful tool for the evaluation of novel insulin secretagogues or other therapeutic agents that directly and/or indirectly target human beta cells. (C) 2013 Elsevier Inc. All rights reserved.
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Mahoney, Luther, Chia-Ming Wu, Harrison S. Kibombo, Eagappanath Thiruppathi, Jonas Baltrusaitis, Shivatharsiny Rasalingam, and Ranjit T. Koodali. “Exploration of the Role of Anions in the Synthesis of Cr Containing Mesoporous Materials at Room Temperature.” Microporous & Mesoporous Materials170, no. / (2013): 211-25.
 
Abstract: Chromium containing mesoporous silica materials were synthesized via a modified Stöber synthesis at room temperature. The chromium ion loading and the effect of counter ion in the synthesis were studied in detail. The mesoporous materials were extensively characterized by powder X-ray diffraction (XRD), N2 physisorption, Atomic Absorption Spectroscopy (AAS), Fourier-Transform-Infrared Spectroscopy (FT-IR), Diffuse Reflectance Spectroscopy (DRS UV–Vis), hydrogen Temperature-Programmed Reduction (H2-TPR), X-ray Photoelectron Spectroscopy (XPS), and Transmission Electron Microscopy (TEM) studies. A transition from Ia d cubic phase to p6mm hexagonal or wormhole phases was noted as more amounts of chromium were incorporated into the siliceous materials. Chromium species present in the silica matrix include monochromate, polychromate, and chromium oxide (Cr2O3) clusters.
 
Chemistry Department.
 
 
Mroch, Amelia R., Mark Laudenschlager, and Jason D. Flanagan. “Detection of a Novel Fh Whole Gene Deletion in the Propositus Leading to Subsequent Prenatal Diagnosis in a Sibship with Fumarase Deficiency.” [In English]. American Journal of Medical Genetics Part A 158A, no. 1 (Jan 2012): 155-58.
 
Fumarase deficiency is a rare autosomal recessive metabolic condition. We report on a sibship with molecularly confirmed fumarase deficiency. Prenatal findings included agenesis of the corpus callosum, ventriculomegaly, and ventriculoseptal defect. The postnatal course was significant for metabolic acidosis ultimately leading to death around 3 weeks of age. Postmortem findings were noted including swollen mitochondria with abnormal cristae on electron microscopy within the liver. Molecular testing revealed a novel whole gene deletion in conjunction with a point mutation. While the point mutation has been previously reported, the detection of a whole gene deletion has not been described to date in an individual with fumarase deficiency. (C) 2011 Wiley Periodicals, Inc.
 
Sanford School of Medicine, Sioux Falls Campus.
 
 
O’Neal, B. C., R. J. Couldry, S. T. Wilkinson, C. A. Cannella, Casey B. Williams, L. A. Scott, and S. Q. Simpson. “Leveraging Drug-Utilization and External Benchmarking Data to Drive Change in Prescribing Behaviors.” [In English]. American Journal of Health-System Pharmacy69, no. 21 (Nov 2012): 1916-22.
 
Purpose. Improved outcomes and cost savings achieved at a large hospital through a drug utilization benchmarking and reporting initiative are described. Summary. Using the University HealthSystem Consortium (UHC) Clinical Resource Manager (CRM) database, the University of Kansas Hospital identified nine target areas (based on Medicare Severity Diagnosis-Related Group) in which the hospital’s drug-utilization practices were deemed suboptimal relative to those of other UHC member facilities with similar caseloads. The pharmacy department developed a CRM template for generating customized reports comparing the hospital’s performance on various drug-utilization metrics with that of top-performing peers (i.e., institutions achieving the best patient care outcomes in terms of mortality and length of stay) in the nine target areas. A pre-post comparison of drug-utilization data collected before and after implementation of the reporting initiative indicated improved outcomes in all nine initially selected target areas, with estimated cumulative annualized cost savings of about $900,000. The CRM-generated reports are now distributed semiannually to attending physicians and other hospital leaders via electronic and hard-copy means, focusing on variances from UHC top-performer and overall UHC averages in the use of higher-cost drugs.The reporting initiative has generally fostered enhanced physician-pharmacist collaboration in the investigation of identified drug-utilization variances and implementation of practice changes. Conclusion. By evaluating service-specific trends of internal drug utilization against external benchmarks and emulating prescribing practices at top-performing institutions, an academic medical center has achieved improved patient care outcomes and cost savings. Am J Health-Syst Pharm. 2012;69:1916-22
 
Sanford School of Medicine, Sioux Falls Campus.
 
 
Parayil, Sreenivasan Koliyat, Jonas Baltrusaitis, Chia-Ming Wu, and Ranjit T. Koodali. “Synthesis and Characterization of Ligand Stabilized Cds-Trititanate Composite Materials for Visible Light-Induced Photocatalytic Water Splitting.” International Journal of Hydrogen Energy38, no. 6 (2013): 2656-69.
 
Abstract: We report a facile method for the synthesis of 4-mercaptobenzoic acid (MBA) stabilized CdS-trititanate nanotube (CdS-TNT) composite materials. The resultant materials were well characterized by powder X-Ray Diffraction (XRD), N2 physisorption, Raman spectroscopy, UV–Visible Diffuse Reflectance spectroscopy (DRS), Fourier-Transform Infra-Red (FT-IR) spectroscopy, Photoluminescence (PL) spectroscopy, X-ray Photoelectron Spectroscopy (XPS), Atomic Absorption Spectroscopy (AAS), and Transmission Electron Microscopy (TEM). The photocatalytic performances of these materials were evaluated by monitoring the amount of hydrogen evolved from water under visible light irradiation. The amount of hydrogen evolved from MBA stabilized CdS-TNT composite materials were higher compared to MBA stabilized CdS, suggesting an important role of the TNT support. The enhanced photocatalytic hydrogen generation in MBA stabilized CdS-TNT composite materials compared to CdS-MBA might have arisen from the effective charge separation in CdS-TNT composite materials, which was further supported by PL studies.
 
Chemistry Department.
 
 
Park, Jisung, and Soonhee Roh. “Daily Spiritual Experiences, Social Support, and Depression among Elderly Korean Immigrants.” Aging & Mental Health17, no. 1 (2013): 102-08.
 
Objectives:This study examined the associations of daily spiritual experiences (DSE) and social support with depression to find viable coping resources and enhance the quality of life among elderly Korean immigrants. Method:We used Smith’s (2003) theory of religious effects and Baron and Kenny’s (1986) approach for mediation analysis to explain the mediating role of social support between DSE and depression. The sample consisted of 200 elderly Korean immigrants who were aged 65 or older (mean age=72.5, range=65–89) living in the New York City Metropolitan area. Hierarchical regression model was used with SPSS version 17.0 to analyze cross-sectional data. Results:Elderly Korean immigrants in the present sample were found to be moderately engaged in DSE but not experiencing a fair level of social support. Respondents reported no depression on the average but 30% of them (60 out of 200 respondents) were experiencing mild to severe depression. Both DSE and social support were inversely related with depression, and the relationship between DSE and depression was mediated by social support. Conclusion:These findings are only suggestive and should not be generalized to a larger population. However, this study supports the importance of DSE and social support in the life of elderly Korean immigrants as a way to alleviate depression. Mental health professionals may consider facilitating social network when elderly Korean immigrants suffer from depression.
 
School of Health Sciences.
 
 
Prescott-Focht, Julia A., S. Martinez-Jimenez, L. M. Hurwitz, J. K. Hoang, J. D. Christensen, B. B. Ghoshhajra, and S. Abbara. “Ascending Thoracic Aorta: Postoperative Imaging Evaluation.” [In English]. Radiographics33, no. 1 (Jan-Feb 2013): 73-85.
 
Advances in computed tomography (CT) scanners and electrocardiographic gating techniques have resulted in superior image quality of the ascending aorta and increased the use of CT angiography for evaluating the postoperative ascending aorta. Several abnormalities of the ascending aorta and aortic arch often require surgery, and various open techniques may be used to reconstruct the aorta, such as the Wheat procedure, in which both an ascending aortic graft and an aortic valve prosthesis are implanted; the Cabrol and modified Bentall procedures, in which a composite synthetic ascending aorta and aortic valve graft are placed; the Ross procedure, in which the aortic valve and aortic root are replaced with the patient’s native pulmonary valve and proximal pulmonary artery; valve-sparing procedures such as the T. David-V technique, which leaves the native aortic valve intact; and more extensive arch repair procedures such as the elephant trunk and arch-first techniques, in which interposition or inclusion grafts are implanted, with or without replacement of the aortic valve. Normal postoperative imaging findings, such as hyper-attenuating felt pledgets, prosthetic conduits, and reanastomosis sites, may mimic pathologic processes. Postoperative complications seen at CT angiography that require further intervention include pseudoaneurysms, anastomotic stenoses, dissections, and aneurysms. Radiologists must be familiar with these procedures and their imaging features to identify normal postoperative appearances and complications.
 
Sanford School of Medicine, Sioux Falls Campus.
 
 
Taub, Gordon E., and Nicholas Benson. “Matters of Consequence: An Empirical Investigation of the Wais-Iii and Wais-Iv and Implications for Addressing the Atkins Intelligence Criterion.” Journal of Forensic Psychology Practice13, no. 1 (2013): 27-48.
 
“Which test provides the better measurement of intelligence, the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) or the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV)?” is an important question to professional psychologists; however, it has become a critical issue in Atkins cases wherein courts are often presented with divergent Full-Scale IQ (FSIQ) scores on the WAIS-III and WAIS-IV. In these instances, courts are required to render a decision stating which test provided the better measure of an inmate’s intellectual functioning. This study employed structural equation modeling to empirically determine which instrument; the WAIS-III or the WAIS-IV, provides the better measure of intelligence via the FSIQ score. Consistent with the publisher’s representation of intellectual functioning, the results from this study indicate the WAIS-IV provides superior measurement, scoring, and structural models to measure FSIQ when compared to the WAIS-III.
 
School of Education.
 
 
Wang, Xuejun, J. Scott Pattison, and Huabo Su. “Posttranslational Modification and Quality Control.” [In English]. Circulation Research112, no. 2 (Jan 2013): 367-81.
 
Protein quality control functions to minimize the level and toxicity of misfolded proteins in the cell. Protein quality control is performed by intricate collaboration among chaperones and target protein degradation. The latter is performed primarily by the ubiquitin-proteasome system and perhaps autophagy. Terminally misfolded proteins that are not timely removed tend to form aggregates. Their clearance requires macroautophagy. Macroautophagy serves in intracellular quality control also by selectively segregating defective organelles (eg, mitochondria) and targeting them for degradation by the lysosome. Inadequate protein quality control is observed in a large subset of failing human hearts with a variety of causes, and its pathogenic role has been experimentally demonstrated. Multiple posttranslational modifications can occur to substrate proteins and protein quality control machineries, promoting or hindering the removal of the misfolded proteins. This article highlights recent advances in posttranslational modification-mediated regulation of intracellular quality control mechanisms and its known involvement in cardiac pathology. (Circ Res. 2013;112:367-381.)
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Wang, Xuejun, and Erin J. M. Terpstra. “Ubiquitin Receptors and Protein Quality Control.” [In English]. Journal of molecular and cellular cardiology55 (2013 Feb (Epub 2012 Oct 2013): 73-84.
 
Protein quality control (PQC) is essential to intracellular proteostasis and is carried out by sophisticated collaboration between molecular chaperones and targeted protein degradation. The latter is performed by proteasome-mediated degradation, chaperone-mediated autophagy (CMA), and selective macroautophagy, and collectively serves as the final line of defense of PQC. Ubiquitination and subsequently ubiquitin (Ub) receptor proteins (e.g., p62 and ubiquilins) are important common factors for targeting misfolded proteins to multiple quality control destinies, including the proteasome, lysosomes, and perhaps aggresomes, as well as for triggering mitophagy to remove defective mitochondria. PQC inadequacy, particularly proteasome functional insufficiency, has been shown to participate in cardiac pathogenesis. Tremendous advances have been made in unveiling the changes of PQC in cardiac diseases. However, the investigation into the molecular pathways regulating PQC in cardiac (patho)physiology, including the function of most ubiquitin receptor proteins in the heart, has only recently been initiated. A better understanding of molecular mechanisms governing PQC in cardiac physiology and pathology will undoubtedly provide new insights into cardiac pathogenesis and promote the search for novel therapeutic strategies to more effectively battle heart disease.This article is part of a Special Issue entitled “Focus on Cardiac Metabolism”. Copyright 2012. Published by Elsevier Ltd.
 
Basic Biomedical Sciences, Vermillion Campus.
 
 
Watson, Allison P., Rick L. Evans, and Kristi A. Egland. “Multiple Functions of Sushi Domain Containing 2 (Susd2) in Breast Tumorigenesis.” [In English]. Molecular Cancer Research11, no. 1 (Jan 2013): 74-85.
 
Routinely used therapies are not adequate to treat the heterogeneity of breast cancer, and consequently, more therapeutic targets are desperately needed. To identify novel targets, we generated a breast cancer cDNA library enriched for genes that encode membrane and secreted proteins. From this library we identified SUSD2 (Sushi Domain Containing 2), which encodes an 822-amino acid protein containing a transmembrane domain and functional domains inherent to adhesion molecules. Previous studies describe the mouse homolog, Susd2, but there are no studies on the human gene associated with breast cancer. Immunohistochemical analysis of human breast tissues showed weak or no expression of SUSD2 in normal epithelial cells, with the endothelial lining of vessels staining positive for SUSD2. However, staining was observed in pathologic breast lesions and in lobular and ductal carcinomas. SUSD2 interacts with galectin-1 (Gal-1), a 14-kDa secreted protein that is synthesized by carcinoma cells and promotes tumor immune evasion, angiogenesis, and metastasis. Interestingly, we found that localization of Gal-1 on the surface of cells is dependent on the presence of SUSD2. Various phenotype assays indicate that SUSD2 increases the invasion of breast cancer cells and contributes to a potential immune evasion mechanism through induction of apoptosis of Jurkat T cells. Using a syngeneic mouse model, we observed accelerated tumor formation and decreased survival in mice with tumors expressing Susd2. We found significantly fewer CD4 tumor infiltrating lymphocytes in mice with tumors expressing Susd2. Together, our findings provide evidence that SUSD2 may represent a promising therapeutic target for breast cancer. Mol Cancer Res; 11(1); 74-85. (c) 2012 AACR.
 
Sanford School of Medicine, Sioux Falls Campus.
 
 
Wu, C. M., M. Rathi, S. P. Ahrenkiel, R. T. Koodali, and Z. Q. Wang. “Facile Synthesis of Mof-5 Confined in Sba-15 Hybrid Material with Enhanced Hydrostability.” [In English]. Chemical Communications49, no. 12 (2013): 1223-25.
 
A MOF-5 [Zn(4)O(BDC)(3); BDC = 1,4-benzenedicarboxylate]@SBA-15 hybrid material has been prepared by using SBA-15 as a matrix. This hybrid material exhibits improved hydrostability under ambient conditions and unique gas adsorption behavior compared with pristine MOF-5.
 
Chemistry Department.
 
 
Zaman, Mohd Saif, Diane M. Maher, Sheema Khan, Meena Jaggi, and Subhash C. Chauhan. “Current Status and Implications of Micrornas in Ovarian Cancer Diagnosis and Therapy.” [In English]. Journal of ovarian research5, no. 1 (2012 2012): 44.
 
ABSTRACT: Ovarian cancer is the fifth most common cancer among women and causes more deaths than any other type of female reproductive cancer. Currently, treatment of ovarian cancer is based on the combination of surgery and chemotherapy. While recurrent ovarian cancer responds to additional chemotherapy treatments, the progression-free interval becomes shorter after each cycle, as chemo-resistance increases until the disease becomes incurable. There is, therefore, a strong need for prognostic and predictive markers to help optimize and personalize treatment in order to improve the outcome of ovarian cancer. An increasing number of studies indicate an essential role for microRNAs in ovarian cancer progression and chemo-resistance. MicroRNAs (miRNAs) are small endogenous non-coding RNAs (~22bp) which are frequently dysregulated in cancer. Typically, miRNAs are involved in crucial biological processes, including development, differentiation, apoptosis and proliferation. Two families of miRNAs, miR-200 and let-7, are frequently dysregulated in ovarian cancer and have been associated with poor prognosis. Both have been implicated in the regulation of epithelial-to-mesenchymal transition, a cellular transition associated with tumor aggressiveness, tumor invasion and chemo-resistance. Moreover, miRNAs also have possible implications for improving cancer diagnosis; for example miR-200 family, let-7 family, miR-21 and miR-214 may be useful in diagnostic tests to help detect ovarian cancer at an early stage. Additionally, the use of multiple target O-modified antagomirs (MTG-AMO) to inhibit oncogenic miRNAs and miRNA replacement therapy for tumor suppressor miRNAs are essential tools for miRNA based cancer therapeutics. In this review we describe the current status of the role miRNAs play in ovarian cancer and focus on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools.
 
Sanford School of Medicine, Sioux Falls Campus.
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