Posted by: princekhaled | September 7, 2010

August 2010

Akkad, Wafa, Bassel Salem, Jerome W. Freeman, and Mark K. Huntington. (2010). 

“Longitudinally Extensive Transverse Myelitis Following Vaccination with Nasal Attenuated Novel Influenza a(H1n1) Vaccine.” Archives of Neurology. 67, no. (Aug): 1018-20.

Background: Transverse myelitis has been reported in association with vaccination, including influenza vaccination. Objective: To describe a case of longitudinally extensive transverse myelitis associated with vaccination with a nasal attenuated novel influenza A(H1N1) vaccine. Design: Case report. Setting: Sanford University of South Dakota Hospital. Patient: A 27-year-old woman with longitudinally extensive transverse myelitis. Results: Four days following novel influenza A(H1N1) vaccination, the patient developed longitudinally extensive transverse myelitis. Extensive diagnostic evaluation effectively ruled out causes other than vaccination-associated transverse myelitis. Following treatment with corticosteroids and plasmapheresis, the patient made a significant recovery. Conclusions: Transverse myelitis may be associated with vaccination against novel influenza A(H1N1). Additionally, we believe this to be the first report of longitudinally extensive transverse myelitis associated with any vaccine.

Sanford School of Medicine, Sioux Falls Campus.


Bhowmik, D., H. Chen, R. R. Aparasu, and V. Bhatara. (2010).

 “Risk of Weight Gain with the Use of Selective Serotonin Reuptake Inhibitors (Ssri) and Atypical Antipsychotics (Sga) Combination Treatment in Children and Adolescents.” Value in Health. 13, no. (May): A180-A81.

Sanford School of Medicine, Sioux Falls Campus.


Carlson, Janet F., Nicholas Benson, and T. Oakland. (2010).

  “Implications of the   International Classification of Functioning, Disability and Health (Icf) for Test Development and Use.” School Psychology International. 31, no. (Aug): 353-71.

Implications of the International Classification of Functioning, Disability and Health (ICF) on the development and use of tests in school settings are enumerated. We predict increased demand for behavioural assessments that consider a person’s activities, participation and person-environment interactions, including measures that: (a) address contextual features; (b) rely on third-party respondents; (c) depend on observational approaches; (d) comprise batteries of tests developed simultaneously or co-normed and (e) emphasize process and progress monitoring. We review some tests from the United States that respond to each emerging demand and describe the international implications of these demands. We close by describing the implications of the ICF model and its associated changes in testing practices for service delivery and student outcomes.

School of Education


Eyster, Kathleen M., Keith A. Hansen, Emily Winterton, Olga Klinkova, Donis Drappeau, and Connie J. Mark-Kappeler. (2010).

“Reciprocal Communication between Endometrial Stromal Cells and Macrophages.” Reproductive Sciences. 17809-22.

 This study tested the hypothesis that reciprocal communication occurs between macrophages and cultured human endometrial stromal cells and that this communication may contribute to the pathology of endometriosis. An endometrial stromal cell line (telomerase-immortalized human endometrial stromal cell [T-HESC]) was treated with macrophage-conditioned medium (CM) ± estradiol + progesterone. Macrophages were treated without or with T-HESC CM. DNA microarray identified 716 differentially expressed genes in T-HESCs in response to factors secreted by macrophages. Upregulated genes in T-HESC included interleukin 8 (IL-8)/chemokine (C-X-C motif) ligand 8 (CXCL8), matrix metalloproteinase 3 (MMP3), phospholamban, cysteine-rich angiogenic inducer 61 (CYR61), connective tissue growth factor (CTGF), tenascin C, and nicotinamide N-methyltransferase (NNMT), whereas integrin α-6 was downregulated. In contrast, 15 named genes were differentially expressed in macrophages in response to factors secreted by endometrial stromal cells. The data document reciprocal communication between macrophages and endometrial stromal cells and suggest that interaction with macrophages stimulates the expression of genes in endometrial stromal cells that may support the establishment of endometriosis.

 Basic Biomedical Sciences, Vermillion Campus


 Gerdes, Anthony Martin, and Giorgio Iervasi. (2010).

“Thyroid Replacement Therapy and Heart Failure.” Circulation. 122, no. (Jul): 385-93. 

Review Article.

Sanford School of Medicine, Sioux Falls Campus.


González-Olivares, Eduardo, Jaime Mena-Lorca, Alejandro Rojas-Palma, and José D. Flores. (2011).

“Dynamical Complexities in the Leslie–Gower Predator–Prey Model as Consequences of the Allee Effect on Prey.” Applied Mathematical Modelling. 35366-81.

Abstract: This work deals with the analysis of a predator–prey model derived from the Leslie–Gower type model, where the most common mathematical form to express the Allee effect in the prey growth function is considered. It is well-known that the Leslie–Gower model has a unique globally asymptotically stable equilibrium point. However, it is shown here the Allee effect significantly modifies the original system dynamics, as the studied model involves many non-topological equivalent behaviors. None, one or two equilibrium points can exist at the interior of the first quadrant of the modified Leslie–Gower model with strong Allee effect on prey. However, a collapse may be seen when two positive equilibrium points exist. Moreover, we proved the existence of parameter subsets for which the system can have: a cusp point (Bogdanov–Takens bifurcation), homoclinic curves (homoclinic bifurcation), Hopf bifurcation and the existence of two limit cycles, the innermost stable and the outermost unstable, in inverse stability as they usually appear in the Gause-type predator–prey models. In contrast, the system modelling an special of weak Allee effect, may include none or just one positive equilibrium point and no homoclinic curve; the latter implies a significant difference between the mathematical properties of these forms of the phenomenon, although both systems show some rich and interesting dynamics.

Mathematics Department.


Keifer, Joyce, and Z. Zheng. (2010).

“Ampa Receptor Trafficking and Learning.” European Journal of Neuroscience. 32, no. (Jul): 269-77.

In the last few years it has become clear that AMPA-type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory, as well as disease states involving cognitive dysfunction. Here, we summarize the evidence for AMPAR trafficking as a mechanism underlying a variety of learned responses derived from both behavioral and cellular studies. Evidence is also reviewed supporting synaptic dysfunction related to impaired AMPAR trafficking as a mechanism underlying learning and memory deficits in Alzheimer’s disease. We conclude that emerging data support the concept of multistage AMPAR trafficking during learning and that a broad approach to include examination of all of the AMPAR subunits will provide a more complete view of the mechanisms underlying multiple forms of learning.

Basic Biomedical Sciences, Vermillion Campus.


Koerner, Susan Silverberg, Yumi Shirai, and DenYelle Baete Kenyon. (2010).

“Sociocontextual Circumstances in Daily Stress Reactivity among Caregivers for Elder Relatives.” Journals of Gerontology Series   Psychological Sciences & Social Sciences. 65B561-72.

Using a daily diary design, we examined whether emotional and physical reactivity in the face of care-related stressors is more intense for caregivers (CGs) living with lower levels of available socioemotional support and higher numbers of extrinsic stressors. Sixty-three CGs reported their experiences based on the past 24 hr (i.e., number of caregiving tasks, care recipient problem behaviors, family disagreements regarding care, depressive symptoms, feelings of burden, physical symptoms) on eight consecutive survey days; they also reported on extrinsic stressors and available socioemotional support. Multilevel analyses indicated significant moderator effects: within-person patterns of reactivity to care-related stressors were especially strong for CGs with lower levels of available socioemotional support and higher numbers of extrinsic stressors. For example, managing additional care recipient problem behaviors on a given day was more strongly associated with increased depressive and physical health symptoms as well as feelings of burden for CGs with relatively high numbers of extrinsic stressors. Implications for intervention are discussed.

Sanford School of Medicine, Sioux Falls Campus


Schlenker, Evelyn H. (2010).

“In Dystrophic Hamsters Losartan Affects Control of Ventilation and Dopamine D1 Receptor Density.” Respiratory Physiology & Neurobiology. 17371-78.

Abstract: The BIO 14.6 hamster (DV), an animal model of limb-girdle muscular dystrophy, has elevated angiotensin AT1 receptors that may affect ventilation. Moreover, AT1 receptors may modulate expression of dopamine D1 receptors. We investigated if chronic treatment of BIO 14.6 hamsters (DL) with losartan, an AT1 receptor blocker, affects D1 receptor density in the striatum and nucleus tractus solitarius (NTS) and normalizes ventilation during exposure to air, hypoxia, following hypoxia, and hypercapnia, Ventilation was evaluated using plethysmography. Compared to the golden Syrian hamsters (GS), DV hamsters exhibited lower hypercapnic and hypoxic responsiveness and ventilation during hypercapnic exposure. Relative to GS, DL hamsters increased breathing frequency in air and maintained ventilation during hypercapnia. Post-hypoxic minute ventilation decline occurred in DV but not in DL or GS hamsters. DL hamsters exhibited higher D1 receptor density in the striatum and NTS relative to DV hamsters. Thus, in dystrophic hamsters chronic losartan treatment stimulated frequency of breathing and increased the density of D1 receptors.

Basic Biomedical Sciences, Vermillion Campus.


Wang, Xuejuu J., and Huabo B. Su. (2010).

“Unraveling Enigma in the Z-Disk.” Circulation Research. 107, no. (Aug): 321-23.


Basic Biomedical Sciences, Vermillion Campus.


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